SentroBlender is a laboratory scale system dedicated to the development of NIR methods using very low amounts of material. The development of NIR PAT methods can be time consuming and expensive. The amount of API required, as well as the overall time including preparation, discharging and cleaning can be excessive, depending on the size of the blender. Using mainly NIR spectra from mixtures taken under static conditions without rotation for the method development is often not representative of a scalable blender.
SentroBlender helps shorten the development time to a minimum while minimizing the amount of required material.
It will take only 1-2 days to get NIR data of 30 – 40 small batches (50 – 100 g each) covering all the required composition variation needed to build robust NIR methods. The system can be used with any Sen¬tronic PAT NIR for container blending (SentroPAT BU and SentroPAT DA). The method transfer to large scale can be accomplished by adding data from a small number of batches acquired at the larger scale into the NIR method. Due to the small size of the overall system, it is possible to insert the system optionally into a glove box to allow handling of highly potent products. The sample holder is designed for using a wide range of different sample bins or bottles.
Optimized 2” squared bins are available as an accessory for the SentroBlender. Alternatively sample containers with an opening of up to 124 x 124mm and a height of up to 175mm can be used.
The holder can be pre-adjusted to a given bin height. The sample containers are pressed against the sapphire window with a spring, enabling fast and easy replacement of samples. The system can be operated at a speed of up to 30 rpm. A predefined position moves the SentroBlender with the bin down to replace it with the next sample. The opposite orientation can be used to acquire a reference spectrum.
A touch panel is used to operate the SentroBlender. The program is intuitive and and is quick and easy to use. During the blending process a counter displays the remaining time or number of revolutions.
© Copyright 2024 MK TEKNOLOGY1 PRIVATE LIMITED. All Rights Reserved.
Designed and Developed by Digital TopGuns